Polyamine blockade promotes antitumor immunity
نویسندگان
چکیده
The levels of polyamines are elevated in neoplastic lesions as compared with normal tissues, and cancer cells tend to manifest a robust dependence on these compounds for proliferation and survival. We have recently demonstrated that a novel approach to polyamine depletion suppresses tumor growth in a T cell-dependent manner, highlighting a poorly appreciated role of polyamines as strong modulators of antitumor immune responses.
منابع مشابه
Effect of a bis(benzyl)polyamine analogue, and DL-alpha-difluoromethylornithine on parasite suppression and cellular polyamine levels in golden hamster during Leishmania donovani
the Th subset response and alters the course of experimental Leishmania major infection. Eur. J. Immunol. 28, 4213–4220 34 Heinzel, F.P. and Maier, R.A.Jr. (1999) Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA-4 antibody. Infect. Immun. 67, 6454–6460 35 Leach, D.R. et al. (1996) Enhancement of antitumor immunity by...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2014